Get AID for Immunoglobulin Diversity PDF

By Frederick W. Alt

ISBN-10: 0123737060

ISBN-13: 9780123737069

Advances in Immunology, a protracted validated and hugely revered serial, offers present advancements in addition to complete stories in immunology. Articles tackle the big variety of subject matters that include immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and medical modalities. Edited and authored by way of the key scientists within the box, each one quantity offers up to date details and instructions for destiny examine.

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Extra info for AID for Immunoglobulin Diversity

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201, 2011–2021. , Lee, C. , and Honjo, T. (1998). Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. Immunity 9, 849–858. , and Bennett, S. E. (2005). Physical and functional interaction of human nuclear uracil‐DNA glycosylase with proliferating cell nuclear antigen. ) 4, 1421–1431. , and Maizels, N. (2001). DNA breaks in hypermutating immunoglobulin genes: Evidence for a break‐and‐repair pathway of somatic hypermutation. Genetics 158, 369–378.

Mutations at arginine 276 transform human uracil‐DNA glycosylase into a single‐stranded DNA‐specific uracil‐DNA glycosylase. ) 4, 793–805. , Kearney, J. , Mansky, L. , and Benichou, S. (2004). Vpr‐mediated incorporation of UNG2 into HIV‐1 particles is required to modulate the virus mutation rate and for replication in macrophages. J. Biol. Chem. 279, 28419–28425. , and Navaratnam, N. (2003). The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense‐mediated decay.

APOBEC1: An RNA‐Editing Enzyme That Can Also Act on DNA.................................. APOBEC2: A Muscle‐Specific Family Member of Unknown Function/Activity ................ APOBEC4: A Distant or Ancestral Member of the AID/APOBEC Family ....................... APOBEC3s: DNA Deaminases Active in Viral Restriction.............................................. Conclusion ................................................................................................................ References ................................................................................................................

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AID for Immunoglobulin Diversity by Frederick W. Alt


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