Advances in Cancer Research, Vol. 77 by George F. Vande Woude, George Klein PDF

By George F. Vande Woude, George Klein

ISBN-10: 0120066777

ISBN-13: 9780120066773

Advances in melanoma learn presents precious details at the intriguing and fast-moving box of melanoma learn. right here once more, extraordinary and unique stories are awarded. Key beneficial properties * The Yin Yang of TCF/b-Catenin Signalling * Biochemical and scientific Implications of the Erb/HER Signaling community of development issue Receptors * p53 and Human melanoma: the 1st 10000 Mutations * Macrophage Stimulating Protein * CD44 Glycoproteins in Colorectal melanoma; Expression; functionality; and Prognostic price * an easy Modes for Carcinogenesis of Colorectal melanoma with Microsatellite Instability

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Morin, P. , Sparks, A. , and Kinzler, K. (1997). Science 275, 1787–1790. Moser, A. , Dove, W. , Roth, K. , and Gordon, J. I. (1992). J. Cell Biol. 116, 1517–1526. , and Polakis, P. (1995). Proc. Natl. Acad. Sci. A. 92, 3046–3050. , and Nakamura, Y. (1998). Cancer Res. 58, 5176–5181. , and Nusse, R. (1994). Nature (London) 367, 80–83. , and Varmus, H. (1982). ) 31, 99–109. , and Grosschedl, R. (1998). Immunity 8, 11–20. , and Clevers, H. (1993). Development (Cambridge, UK) 118, 439–448. , and Byers, S.

And Bienz, M. (1997). ) 88, 777–787. , and Mello, C. (1997). ) 90, 707–716. , and Clevers, H. (1998). Nature (London) 395, 608–612. , Chamberlain, S. , Masiarz, F. , and Polakis, P. (1993). Science 262, 1731–1734. , and Polakis, P. (1996). Science 272, 1023–1026. , and Polakis, P. (1997). Science 275, 17990–1792. , and Melton, D. (1991). ) 67, 741–752. , and Kinzler, K. (1998). Cancer Res. 58, 1130–1134. Su, L. , and Kinzler, K. (1993). Science 262, 1734–1736. , and Bowerman, B. (1997). ) 90, 695–705.

Its four zones show a high diversity between the family members as presented in percentage of homology to the first identified receptor, ErbB-1. This diversity confers specific primary recognition of multiple ligands as listed for each of the receptors. Specificity is extended by cross-reactivity of several of the ligands; NRG1 and NRG2 are shared by ErbB-3 and ErbB-4; betacellulin, epiregulin, and HB-EGF are recognized by both ErbB-1 and ErbB-4. ErbB2 is ligandless. High homology of the cytoplasmic tyrosine kinase domain is altered in the case of ErbB-3 that is catalytically impaired.

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Advances in Cancer Research, Vol. 77 by George F. Vande Woude, George Klein

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